06277384 is referenced by 144 patents and cites 79 patents.

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

Title
Opioid agonist/antagonist combinations
Application Number
9/218662
Publication Number
6277384 (B1)
Application Date
December 22, 1998
Publication Date
August 21, 2001
Inventor
Robert D Colucci
Newtown
CT, US
Robert F Kaiko
Weston
CT, US
Agent
Davidson Davidson & Kappell
US
Assignee
Euro Celtique
US
IPC
A61K 9/00
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