06262079 is referenced by 27 patents and cites 284 patents.

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I):

wherein Z is C═O or a covalent bond; Y is H or O(C

1

-C

4

)alkyl, R

1

and R

2

are individually (C

1

-C

4

)allyl or together with N are a saturated heterocyclic group, R

3

is ethyl or chloroethyl, R

4

is H or together with R

3

is —CH

2

—CH

2

— or —S—, R

5

is I, O(C

1

-C

4

)alkyl or H and R

6

is I, O(C

1

-C

4

)alkyl or H with the proviso that when R

4

F R

5

, and R

6

are H, R

3

is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).

Title
Prevention and treatment of cardiovascular pathologies
Application Number
9/306606
Publication Number
6262079 (B1)
Application Date
May 6, 1999
Publication Date
July 17, 2001
Inventor
Peter L Weissberg
Cambridge
US
Robert W Schroff
Edmonds
WA, US
Lawrence L Kunz
Redmond
WA, US
James C Metcalfe
Cambridge
US
David J Grainger
Cambridge
US
Agent
Schwegman Lundberg Woessner & Kluth P A
US
Assignee
NeoRx Corporation
WA, US
IPC
A61K 31/445
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