06262024 is referenced by 10 patents and cites 1 patents.

A neuron regulatory factor (NRF), derived from cells of the central nervous system, is provided. A cytoprotective peptide (CPP) component of NRF is also provided, as are methods of using NRF or its CPP component. NRF comprises a large polypeptide or complex of polypeptides that is distinct from several other known neurotrophic or neuron regulatory factors. The CPP component of NRF is an acidic protein or protein complex whose amino acid sequence is unique among known protein sequences. Both NRF and its CPP component are capable of promoting survival and neurite outgrowth of cultured neurons in vitro, and preventing neuron degeneration and promoting neuron survival in vivo. The CPP component of NRF also exhibits a cytoprotective effect on non-neuronal cells.

Title
Neuron regulatory factor for promoting neuron survival
Application Number
8/936477
Publication Number
6262024 (B1)
Application Date
September 18, 1997
Publication Date
July 17, 2001
Inventor
Sarah E Kennedy
Ambler
PA, US
Pat R Levitt
Wyncote
PA, US
Kathie L Eagleson
Somerville
NJ, US
Forrest Haun
Wyncote
PA, US
Timothy J Cunningham
Fort Washington
PA, US
Agent
Dann Dorfman Herrell and Skillman
US
Assignee
Philadelphia Health and Education Corporation
PA, US
IPC
C07K 14/475
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