06258562 is referenced by 236 patents and cites 18 patents.

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor &agr;(hTNF&agr;) are disclosed. These antibodies have high affinity for hTNF&agr; (e.g., K

d

=10

−8

M or less), a slow off rate for hTNF&agr; dissociation (e.g., K

off

=10

−3

sec

−1

or less) and neutralize hTNF&agr; activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF&agr; and for inhibiting hTNF&agr; activity, e.g., in a human subject suffering from a disorder in which hTNF&agr; activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

Title
Human antibodies that bind human TNF&agr;
Application Number
9/125098
Publication Number
6258562 (B1)
Application Date
March 16, 1999
Publication Date
July 10, 2001
Inventor
Alison J Wilton
Cambridge
US
Michael White
Framingham
MA, US
Tristan J Vaughan
Impington
US
David Schoenhaut
Garfield
NJ, US
Paul Sakorafas
Newton
MA, US
Andrew J Roberts
Cambridge
US
Brian T McGuinness
Comberton
US
John A Mankovich
Andover
MA, US
Boris Labkovsky
Framingham
MA, US
Zehra Kaymakcalan
Westboro
MA, US
Hendricus R J M Hoogenboom
Hertogsingel
MA, US
Deborah J Allen
Cambridge
US
Jochen G Salfeld
North Grafton
MA, US
Agent
Lahive & Cockfield
US
Agent
Elizabeth A Hanley
US
Giulio A DeConti Jr
US
Assignee
BASF Aktiengesellschaft
US
IPC
C07M 21/00
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