06248345 is referenced by 100 patents and cites 128 patents.

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally and a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

Title
Prolonged anesthesia in joints and body spaces
Application Number
9/109324
Publication Number
6248345 (B1)
Application Date
July 2, 1998
Publication Date
June 19, 2001
Inventor
Richard Sackler
Greenwich
CT, US
Mark Chasin
Manalapan
NJ, US
Donna Donigi Gale
Richfield
CT, US
Peter Lacouture
Newton
CT, US
Paul Goldenheim
Wilton
CT, US
Agent
Davidson Davidson & Kappel
US
Assignee
Euro Celtique
US
IPC
A61F 2/02
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