06241771 is referenced by 431 patents and cites 47 patents.

A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25-100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

Title
Resorbable interbody spinal fusion devices
Application Number
9/131716
Publication Number
6241771 (B1)
Application Date
August 10, 1998
Publication Date
June 5, 2001
Inventor
Donald L Wise
Belmont
MA, US
Alexander M Klibanov
Newton
MA, US
Kai Uwe Lewandrowski
Brookline
MA, US
Robert S Langer
Newton
MA, US
Debra J Trantolo
Princeton
MA, US
Joseph D Gresser
Brookline
MA, US
Agent
Weingarten Schurgin Gagnebin & Hayes
US
Assignee
Cambridge Scientific
MA, US
IPC
A61F 2/44
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