06238702 is referenced by 113 patents and cites 132 patents.

A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled release material to obtain a. reversible nerve blockade or anesthesia effect when implanted or injected in a patient, and a non-toxic glucocorticosteroid agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the glucocorticosteroid agent.

Title
High load formulations and methods for providing prolonged local anesthesia
Application Number
9/352511
Publication Number
6238702 (B1)
Application Date
July 12, 1999
Publication Date
May 29, 2001
Inventor
Jenny Castillo
Philadelphia
PA, US
Joanne Curley
San Jose
CA, US
Robert S Langer
Newton
MA, US
Charles B Berde
Brookline
MA, US
Agent
Davidson Davidson & Kappel
US
Assignee
Children&apos s Medical Center
MA, US
IPC
A61K 9/14
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