06231600 is referenced by 426 patents and cites 172 patents.

A device such as a stent is provided with a hybrid coating including a time released, restenosis inhibiting coating and a non-thrombogenic coating to prevent clotting on the device. One first coat or layer includes a polymer, a crosslinking agent, and pacitaxel, analogues, or derivatives thereof. The first coat preferably includes a polymer having Taxol admixed therein so as to be releasable over time. The first coat preferably includes a polyfunctional aziridine as the crosslinking agent. The second coat preferably includes heparin to inhibit clot formation on the device. The crosslinking agent can covalently bond to both the first coat polymer and the second coat heparin. A stent can be provided with a first coat including an aqueous dispersion or emulsion of a polymer and an excess of crosslinking agent. The first coating can be dried, leaving a water insoluble polymer coating. A second aqueous coating including a solution or dispersion of heparin can be applied over the first coating, the heparin becoming covalently bound to the crosslinking agent on the first coating surface. The resulting stent can inhibit restenosis while preventing blood clot formation on the stent.

Title
Stents with hybrid coating for medical devices
Application Number
9/320340
Publication Number
6231600 (B1)
Application Date
May 26, 1999
Publication Date
May 15, 2001
Inventor
Sheng ping Zhong
Northborough
MA, US
Agent
Crompton Seager & Tufte
US
Assignee
SciMed Life Systems
MN, US
IPC
A61I 2/06
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