06228863 is referenced by 242 patents and cites 79 patents.

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

Title
Method of preventing abuse of opioid dosage forms
Application Number
9/218663
Publication Number
6228863 (B1)
Application Date
December 22, 1998
Publication Date
May 8, 2001
Inventor
Robert F Kaiko
Weston
CT, US
Robert D Colucci
Newtown
CT, US
Philip J Palermo
Bethel
CT, US
Agent
Davidson Davidson & Kappel
US
Assignee
Euro Celtique
US
IPC
A61K 31/44
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