06225460 is referenced by 49 patents and cites 58 patents.

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

Title
Nucleotide analogs
Application Number
9/247497
Publication Number
6225460 (B1)
Application Date
February 10, 1999
Publication Date
May 1, 2001
Inventor
Kenneth C Cundy
Belmont
CA, US
William A Lee
Los Altos
CA, US
Ernest J Prisbe
Los Altos
CA, US
Lawrence R McGee
Pacifica
CA, US
Michael S Louie
San Mateo
CA, US
Kuei Ying Lin
Fremont
CA, US
Murty N Arimilli
Fremont
CA, US
Robert J Jones
Millbrae
CA, US
Norbert W Bischofberger
San Carlos
CA, US
Agent
Max D Hensley
US
Assignee
Gilead Sciences
CA, US
IPC
C07H 19/04
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