06221645 is referenced by 37 patents and cites 2 patents.

Compositions comprising a novel protease capable of cleaving &bgr;-amyloid precursor protein (APP) on the amino-terminal side of the &bgr;-amyloid peptide therein are provided. The protease is designated &bgr;-secretase. Reaction systems comprising &bgr;-secretase may be used in screening assays to monitor &bgr;-secretase modulated cleavage of APP and to identify &bgr;-secretase inhibitors, wherein the &bgr;-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of &bgr;-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

Title
&bgr;-secretase antibody
Application Number
8/660531
Publication Number
6221645 (B1)
Application Date
June 7, 1996
Publication Date
April 24, 2001
Inventor
Lisa Clair McConlogue
San Francisco
CA, US
Hua Tan
Daly City
CA, US
John P Anderson
San Francisco
CA, US
Pamela S Keim
San Mateo
CA, US
Sukanto Sinha
San Francisco
CA, US
Susanna M S Chrysler
San Bruno
CA, US
Assignee
Elan Pharmaceuticals
CA, US
IPC
C07K 16/00
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