When fabricating a liquid crystal panel from a pair of substrates using the “one-drop fill” method to deposit liquid crystal material in a central portion of one substrate and then sealing the substrates together with a fillet of epoxy between the outer peripheral portions of the substrates, the uncured epoxy tends to contaminate the liquid crystal material and impair its function. Here, a relatively thick barrier fillet, as of silicone elastomer, is deposited in the form of a continuous closed circuit upon one of the substrates and is fully cured before depositing the liquid crystal material within that closed circuit. To seal the substrates together, they are brought together to a spacing determined by a relatively thin spacer fillet provided on one of the substrates and an epoxy fillet is deposited along the outer periphery of the substrates. The barrier fillet, preferably compressed, serves to prevent contamination of the liquid crystal material by any regions of uncured epoxy. In one variation, the epoxy fillet is formed from a two-component epoxy by depositing a continuous circuit of one component to surround the barrier fillet on one substrate and depositing an identical continuous circuit of the other component on the other substrate before joining the substrates together to intermix and cause cross-linking of the the components to form a cured epoxy fillet.