06214049 is referenced by 170 patents and cites 60 patents.

Bone augmentation in a mammalian body to enhance the mechanical strength of a prosthesis is provided by reinforcement of bone in the region surrounding the implant device. A number of fibrillar wires are formed on the prosthetic implant device. Formation of the fibrillar wires comprises gauging the implant device so that the fibrillar wires are formed by peeling them from the implant device. Alternatively, formation of the fibrillar wires may comprise forming a mesh of fibrillar wires having a woolly structure, forming the mesh around the prosthetic implant device, and attaching a number of the fibrillar wires to the prosthetic implant device. A coating is formed on the fibrillar wires and an associated prosthetic implant device. The coating comprises bone morphogenetic proteins along with osteoinductive factors and osteoconductive factors that function as nutrients, anti-microbial and anti-inflammatory agents, and blood-clotting factors. The polymer is a polymer matrix component comprising lactic acid, glycolic acid, and copolymers of lactic acid and glycolic acid. The osteoinductive coating combined with the fibrillar wool or prongs should allow for optimal osteointegration and physiologic load distribution of a implant device resulting in prosthetic success when placed in the human body.

Title
Method and apparatus for augmentating osteointegration of prosthetic implant devices
Application Number
9/231907
Publication Number
6214049 (B1)
Application Date
January 14, 1999
Publication Date
April 10, 2001
Inventor
Christopher J Comfort
Sunnyvale
CA, US
Gregory G Gayer
Burlingame
CA, US
Agent
Blakely Sokoloff Taylor & Zafman
US
Assignee
Comfort Biomedical
CA, US
IPC
A61F 2/28
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