06200597 is referenced by 7 patents and cites 36 patents.

A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid arrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially uniformly distributed with the lipid in the lipid carrier particles. The molar ratio of carotenoid to lipid is greater than about 1:10. Also disclosed is a method of inhibiting the growth of cancer cells, which comprises administering to a living subject a therapeutically effective amount of a composition as described above.

Title
Formulation and use of carotenoids in treatment of cancer
Application Number
9/95672
Publication Number
6200597 (B1)
Application Date
June 10, 1998
Publication Date
March 13, 2001
Inventor
Alan C Hayman
late of The Woodlands
TX, US
Robert Lenk
Willis
TX, US
Gabriel Lopez Berestein
Houston
TX, US
Roman Perez Soler
Houston
TX, US
Kapil Mehta
Houston
TX, US
Agent
Fulbright & Jaworski L
US
Assignee
Aronex Pharmaceuticals
TX, US
Board of Regents The University of Texas System
TX, US
IPC
A61K 9/127
View Original Source