06183461 is referenced by 238 patents and cites 151 patents.

A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assumes an increased profile. After the device is filled, it is allowed to float freely within the body cavity. Alternatively, the device can be tethered to a wall of the body cavity. The device delivers the drug at a controlled rate over an extended period of time. In order to deliver the drug at a controlled rate, the device preferably has a pressure-responsive valving member. The flow resistance of the valving member is responsive to the pressure at which the drug is stored within the infusing device. The resistance of the valving member decreases as the pressure within the infusing device decreases, thereby providing a resultant controlled flow rate.

Title
Method for delivering a medication
Application Number
9/395415
Publication Number
6183461 (B2)
Application Date
September 14, 1999
Publication Date
February 6, 2001
Inventor
Paul F Zupkas
San Diego
CA, US
Mikxay Sirivong
San Diego
CA, US
Charles Lowell Parsons
La Jolla
CA, US
John Patrick Greelis
Carlsbad
CA, US
Walter Dean Gillespie
La Mesa
CA, US
David G Matsuura
Escondido
CA, US
Agent
Knobbe Martens Olsen & Bear
US
Assignee
Situs Corporation
CA, US
IPC
A61M 31/00
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