06169091 is referenced by 71 patents and cites 12 patents.

Substituted heteroaromatic compounds of formula (A) wherein X is N or CH; in which (a) represents a fused 5, 6 or 7-membered heterocyclic ring and R

3

is a group ZR

4

wherein Z is joined to R

4

through a (CH

2

)p group in which p is 0, 1, or 2 and Z represents a group V(CH

2

), V(CF

2

), (CH

2

)V, (CF

2

)V, V(CRR′), V(CHR) or V where R and R′ are each C

1-4

alkyl and in which V is a hydrocarbyl group containing 0, 1 or 2 carbon atoms, carbonyl, dicarbonyl, CH(OH), CH(CN), sulphonamide, amide, O, S(O)

m

or NR

b

where R

b

is hydrogen or R

b

is C

1-4

alkyl; and R

4

is an optionally substituted C

3-6

cycloalkyl or an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety; or R

3

is a group ZR

4

in which Z is NR

b

, and NR

b

and R

4

together form an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety, are protein tyrosine kinase inhibitors. The compounds are described, as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of psoriasis, fibrosis, atherosclerosis, restenosis, auto-immune disease, allergy, asthma, transplantation rejection, inflammation, thrombosis, nervous system diseases, and cancer.

Title
Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
Application Number
9/51324
Publication Number
6169091 (A)
Application Date
August 26, 1998
Publication Date
January 2, 2001
Inventor
Karl Witold Franzmann
London
US
Paul Barraclough
Maidstone
US
Alan Thomas Hudson
Otford
US
Sadie Vile
Stevenage
US
Kathryn Jane Smith
Stevenage
US
Martin John Page
Abingdon
US
Stephen Carl McKeown
Stevenage
US
Stephen Barry Guntrip
Stevenage
US
George Stuart Cockerill
Stevenage
US
Agent
John L Lemanowicz
US
Assignee
Glaxo Wellcome
NC, US
IPC
C07D 487/04
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