06159938 is referenced by 43 patents and cites 19 patents.

Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also provided are methods for detecting or quantifying the activity of a serine protease in a pure sample.

Title
Serine protease inhibitors comprising .alpha.-keto heterocycles
Application Number
345820
Publication Number
6159938
Application Date
May 20, 1997
Publication Date
December 12, 2000
Inventor
John C Cheronis
Conifer
CO, US
Axel H Leimer
Lakewood
CO, US
Lyle W Spruce
Arvada
CO, US
Albert C Gyorkos
Westminster
CO, US
Agent
Dechert
Assignee
Cortech
IPC
C07K 5/062
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