06150584 is referenced by 441 patents and cites 18 patents.

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

Title
Human antibodies derived from immunized xenomice
Application Number
PCTUS9605928
Publication Number
6150584
Application Date
October 2, 1996
Publication Date
November 21, 2000
Inventor
Sue Klapholz
Stanford
CA, US
Daniel J Capon
Hillsborough
CA, US
Daniel G Brenner
Redwood City
CA, US
Aya Jakobovits
Menlo Park
CA, US
Raju Kucherlapati
Darien
CT, US
Agent
Fish & Neave
Agent
Jane T Gunnison
James F Haley Jr
Assignee
Abgenix
CA, US
IPC
C12N 15/00
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