06143948 is referenced by 29 patents and cites 36 patents.

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.

Title
Device for incorporation and release of biologically active agents
Application Number
855833
Publication Number
6143948
Application Date
July 3, 1997
Publication Date
November 7, 2000
Inventor
Klaas De Groot
Heemstede
NL
Hai Bo Wen
Bilthoven
NL
Joost Dick De Bruijn
The Hague
NL
Eugenia Ribeiro de Sousa Fidalgo Leitao
Tytherington
GB
Agent
Banner & Witcoff
Assignee
IsoTis
NL
IPC
A61F 2/02
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