06143322 is referenced by 184 patents and cites 143 patents.

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rpm at 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37.degree. C. of from about 12.5% to about 42.5% (by wt) opioid released after 1 hour, from about 25% to about 65% (by wt) opioid released after 2 hours, from about 45% to about 85% (by wt) opioid released after 4 hours, and greater than about 60% (by wt) opioid released after 8 hours, the in-vitro release rate being substantially independent of pH and chosen such that the peak plasma level of said opioid analgesic obtained in-vivo occurs from about 2 to about 8 hours after administration of the dosage form.

Title
Method of treating humans with opioid formulations having extended controlled release
Application Number
86248
Publication Number
6143322
Application Date
April 8, 1997
Publication Date
November 7, 2000
Inventor
Paul Goldenheim
Wilton
CT, US
Robert Kaiko
Weston
CT, US
Richard Sackler
Greenwich
CT, US
Agent
Davidson Davidson & Kappel
Assignee
Purdue Pharma
CT, US
IPC
A61K 9/14
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