06136295 is referenced by 153 patents and cites 104 patents.

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

Title
Aerodynamically light particles for pulmonary drug delivery
Application Number
655570
Publication Number
6136295
Application Date
December 15, 1998
Publication Date
October 24, 2000
Inventor
Robert S Langer
Newton
MA, US
Abdell Aziz Ben Jebria
State College
PA, US
Justin Hanes
Baltimore
MD, US
Noah Lotan
Haifa
IL
Jeffrey S Hrkach
Somerville
MA, US
Giovanni Caponetti
Piacenza
IT
David A Edwards
State College
PA, US
Agent
Hamilton Brook Smith & Reynolds P C
Assignee
Penn State Research Foundation
PA, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/14
A61F 2/00
A61L 9/04
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