06134461 is referenced by 1107 patents and cites 317 patents.

An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

Title
Electrochemical analyte
Application Number
9/34372
Publication Number
6134461
Application Date
March 4, 1998
Publication Date
October 17, 2000
Inventor
Mark S Vreeke
Alameda
CA, US
Phillip John Plante
Sunnyvale
CA, US
Ephraim Heller
Oakland
CA, US
Behrad Aria
Alameda
CA, US
Yoram Gal
Kibbutz Yagur
IL
Adam Heller
Austin
TX, US
Michael F Tomasco
Cupertino
CA, US
James Say
Alameda
CA, US
Agent
Merchant & Gould P C
Assignee
E Heller & Company
CA, US
IPC
A61B 5/05
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