06123727 is referenced by 86 patents and cites 7 patents.

Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.

Title
Tissue engineered tendons and ligaments
Application Number
431780
Publication Number
6123727
Application Date
August 4, 1997
Publication Date
September 26, 2000
Inventor
Joseph Upton
Brookline
MA, US
Keith Paige
Brookline
MA, US
Joseph P Vacanti
Winchester
MA, US
Robert S Langer
Newton
MA, US
Yi Lin Cao
Shrewsbury
MA, US
Charles A Vacanti
Lexington
MA, US
Agent
Clark & Elbing
Assignee
Cambridge Childern s Medical Center Corproration
MA, US
Massachusetts Institute of Technology
MA, US
IPC
A61F 2/08
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