06120803 is referenced by 150 patents and cites 13 patents.

The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

Title
Prolonged release active agent dosage form adapted for gastric retention
Application Number
9/131923
Publication Number
6120803
Application Date
August 10, 1998
Publication Date
September 19, 2000
Inventor
Jason J Wan
Palo Alto
CA, US
Francisco Jao
San Jose
CA, US
Phyllis I Gardner
Stanford
CA, US
Felix Theeuwes
Los Altos
CA, US
David E Edgren
El Granada
CA, US
Liang Chang Dong
Sunnyvale
CA, US
Patrick S L Wong
Burlingame
CA, US
Agent
Steven F Stone
John A Dhuey
Assignee
ALZA Corporation
CA, US
IPC
A61K 9/26
A61K 9/22
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