06117454 is referenced by 45 patents and cites 33 patents.

A novel method of delivering drugs and diagnostics across the blood-brain barrier or blood-nerve barrier is disclosed. Drugs or diagnostic agents are incorporated into nanoparticles which have been fabricated in conventional ways. These nanoparticles are then coated with additional surfactant and given to the body of animals or humans. This allows drugs or diagnostic agents to cross the blood-brain barrier (bbb) to achieve one or more of the following benefits: (1) reducing the dose of a therapeutic drug or diagnostic agent which, when given peripherally, maintains the biological or diagnostic potency in the nervous system, (2) allowing drugs that normally do not cross the bbb to penetrate into the nervous system, and (3) reducing the peripheral side effects by increasing the relative amount of the drug reaching the brain.

Title
Drug targeting to the nervous system by nanoparticles
Application Number
203326
Publication Number
6117454
Application Date
May 27, 1997
Publication Date
September 12, 2000
Inventor
Bernhard A Sabel
Berlin
DE
Dimitri A Karkevich
Moscow
RU
Renad N Alyautdin
Moscow
RU
Jorg Kreuter
Bad Homburg
DE
Agent
Lahive & Cockfield
Assignee
Medinova Medical Consulting
DE
IPC
A61K 9/51
A61K 9/52
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