06114598 is referenced by 335 patents and cites 13 patents.

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.

Title
Generation of xenogeneic antibodies
Application Number
919297
Publication Number
6114598
Application Date
June 5, 1995
Publication Date
September 5, 2000
Inventor
Daniel J Capon
Hillsborough
CA, US
Daniel G Brenner
Redwood City
CA, US
Sue Kalpholz
Stanford
CA, US
Aya Jakobovits
Menlo Park
CA, US
Raju Kucherlapati
Darien
CT, US
Agent
Fish & Neave
Agent
Jane T Gunnison Esq
James F Haley Jr Esq
Assignee
Abgenix
CA, US
IPC
A61K 48/00
C12N 15/79
C12N 5/10
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