An improved article of footwear, specifically for use in the sport of tennis. The article of footwear addresses motions prevalent in the sport of tennis by enhancing performance and preventing injuries. The article of footwear is asymmetrical and the lateral and medial portions have features to performs different functions to enhance flexibility, balance control, propulsion, stability and support in the specific areas where needed. In part, the medial portion of the article of footwear is designed to provide flexibility while the lateral portion is designed to create stability. These differences in the medial and lateral portions of the article of footwear exist in the upper, e.g., lacing system, material composition, and material thickness differences, and/or in the sole, e.g., different midsole materials, supporting elements effecting only the lateral side.