06103261 is referenced by 173 patents and cites 142 patents.

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer at 37.degree. C. from about 12.5% to about 42.5% (by weight) active agent released after 1 hour, from about 25% to about 55% (by weight) active agent released after 2 hours, from about 45% to about 75% (by weight) opioid analgesic released after 4 hours and greater than about 60% (by weight) opioid analgesic released after a hours, the in-vitro release rate being substantially independent of pH and chosen such that the peak plasma level of active agent obtained in-vivo between about 2 and about 8 hours after administration of the dosage form.

Title
Opioid formulations having extended controlled release
Application Number
86248
Publication Number
6103261
Application Date
January 6, 1999
Publication Date
August 15, 2000
Inventor
Frank Pedi Jr
Yorktown Heights
NY, US
Benjamin Oshlack
New York
NY, US
Mark Chasin
Manalapan
NJ, US
Agent
Davidson Davidson & Kappel
Assignee
Purdue Pharma
CT, US
IPC
A61K 9/14
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