06091976 is referenced by 343 patents and cites 10 patents.

A method for determining and monitoring tissue glucose concentration, wherein a perfusion solution is conveyed as a liquid column through a microdialysis probe implanted in the tissue and is moved to a test cell preferably arranged outside the patient's body, the volumetric flow of the perfusion solution being reduced in its time average for the duration of the dialysis intervals (T.sub.1) and the volume of the perfusion solution perfused through the microdialysis probe during each dialysis interval (T.sub.1) being moved on in a consecutive transport interval (T.sub.2) at a higher volumetric flow to the test cell and wherein the glucose content of the perfusion solution passing through the test cell is determined from continuously detected test signals, characterized in that before passing through the microdialysis probe the perfusion solution is mixed with glucose in order to set a predetermined initial concentration.

Title
Determination of glucose concentration in tissue
Application Number
9/147207
Publication Number
6091976
Application Date
October 28, 1998
Publication Date
July 18, 2000
Inventor
Udo Hoss
Ulm
DE
Margret Pfeiffer
Ulm
DE
Agent
Arent Fox Kintner & Kahn PLLC
Assignee
Roche Diagnostics
DE
IPC
A61B 5/00
A61B 5/05
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