06090382 is referenced by 281 patents and cites 18 patents.

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor .alpha. (hTNF.alpha.) are disclosed. These antibodies have high affinity for hTNF.alpha. (e.g., K.sub.d =10.sup.-8 M or less), a slow off rate for hTNF.alpha. dissociation (e.g., K.sub.off =10.sup.-3 sec.sup.-1 or less) and neutralize hTNF.alpha. activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF.alpha. and for inhibiting hTNF.alpha. activity, e.g., in a human subject suffering from a disorder in which hTNF.alpha. activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

Title
Human antibodies that bind human TNF.alpha.
Application Number
8/599226
Publication Number
6090382
Application Date
February 9, 1996
Publication Date
July 18, 2000
Inventor
Alison J Wilton
Cambridge
GB
Michael White
Framingham
MA, US
Tristan J Vaughan
Impington
GB
David Schoenhaut
Clifton
NJ, US
Paul Sakorafas
Shrewsbury
MA, US
Andrew J Roberts
Cambridge
GB
Brian T McGuinness
Hauxton
GB
John A Mankovich
Andover
MA, US
Boris Labkovsky
Framingham
MA, US
Zehra Kaymakcalan
Westboro
MA, US
Hendricus R J M Hoogenboom
Hasselt
BE
Deborah J Allen
London
GB
Jochen G Salfeld
North Grafton
MA, US
Agent
Lahive & Cockfield
Agent
Elizabeth A Hanley Esq
Catherine J Kara
Assignee
BASF Aktiengesellschaft
DE
IPC
C07K 16/24
A61K 39/395
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