06087327 is referenced by 35 patents and cites 9 patents.

The compositions and methods disclosed herein utilize admixtures of neurotoxins to cause denervation which is unexpectedly more localized and of longer duration than otherwise occurs with single neurotoxins. The compositions and methods of the invention utilize neurotoxin admixtures calibrated in median paralysis units rather than LD.sub.50 s. Admixtures of neurotoxins include, but are not limited to, the botulinum serotypes A-G and tetanus toxin. The clinical benefits of the disclosed invention include: lengthening intervals between neurotoxin treatments; reducing adverse immunogenic responses to neurotoxins; and, reducing adverse diffusion-dependent side-effects of neurotoxin treatments.

Title
Compositions and methods for chemodenervation using neurotoxins
Application Number
465767
Publication Number
6087327
Application Date
January 30, 1998
Publication Date
July 11, 2000
Inventor
Eric R First
52 N St. South, Boston, 02127-2305
MA, US
L Bruce Pearce
16 Partridge Cir., Hudson, 03051
NH, US
Agent
Nutter McClennen & Fish
Agent
Thomas J Engellenner
IPC
A61K 38/16
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