06083710 is referenced by 924 patents and cites 4 patents.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Title
Electrochemical analyte measurement system
Application Number
161682
Publication Number
6083710
Application Date
June 16, 1999
Publication Date
July 4, 2000
Inventor
Michael V Pishko
Austin
TX, US
Adam Heller
Austin
TX, US
Agent
Merchant & Gould P C
Assignee
E Heller & Company
CA, US
IPC
C12M 1/40
C07C 1/00
C12Q 1/28
C12Q 1/54
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