06075181 is referenced by 548 patents and cites 20 patents.

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

Title
Human antibodies derived from immunized xenomice
Application Number
466008
Publication Number
6075181
Application Date
June 7, 1995
Publication Date
June 13, 2000
Inventor
Daniel J Capon
Hillsborough
CA, US
Daniel G Brenner
San Mateo
CA, US
Sue Klapholz
Stanford
CA, US
Aya Jakobovits
Menlo Park
CA, US
Raju Kucherlapati
Darien
CT, US
Agent
Fish & Neave
Agent
Jane T Gunnison
James F Haley Jr
Assignee
Abgenix
CA, US
IPC
C12N 5/00
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