Featured is a method for injection of a payload into the tissues of an organism or a body, including the steps of generating forces by electromagnetic repulsion and accelerating the payload to be injected, using the generated electromagnetic forces. The payload is thereby accelerated to a velocity sufficient for the payload to pass through the skin of the organism and be disposed in the subcutaneous tissues. The method further includes providing an electromagnetic force generating device that generates forces electromagnetically in a predetermined direction responsive to an electric current flowing through the device, wherein the step of generating includes passing an electric current through the electromagnetic force generating device to generate the electromagnetic repulsive forces used for accelerating the payload. Also featured is a electromagnetic force generating mechanism that includes a conductive member, which is configured so as to generate electromagnetic repulsive forces in a given direction to accelerate the payload responsive to a pulsed current passing through the conductive member. Additionally featured is an electromagnetic transdermal injection device including such an electromagnetic force generating mechanism, an electrical power supply and a switch that selectively interconnects the power supply and force generating mechanism to accelerate a payload such as a medicine.