06063637 is referenced by 296 patents and cites 5 patents.

Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl.sup.- release is used. Methods for monitoring the concentrations of sugars and related molecules using the metal based sensors (20, 50, 70) are also disclosed.

Title
Sensors for sugars and other metal binding analytes
Application Number
571440
Publication Number
6063637
Application Date
July 7, 1997
Publication Date
May 16, 2000
Inventor
Guohua Chen
Pasadena
CA, US
Chao Tsen Chen
New York
NY, US
Zhibin Guan
Hockessin
DE, US
Frances H Arnold
Pasadena
CA, US
Agent
Darby & Darby
Assignee
California Institute of Technology
CA, US
IPC
G01N 33/00
G01N 21/00
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