06051684 is referenced by 11 patents and cites 119 patents.

Methods of use of compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds provided for use in the methods are those of the formula: ##STR1## in which R.sub.1 is preferably 2-methylpropenyl, 2-butenyl, cyclohexyl or cyclohexylmethyl; R.sub.2, R.sub.4, and R.sub.8 are each preferably independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is preferably H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; and X is preferably an aldehyde, .alpha.-ketoester or .alpha.-ketoamide.

Title
Methods of treating neurodegenerative disorders using protease inhibitors
Application Number
369422
Publication Number
6051684
Application Date
May 17, 1995
Publication Date
April 18, 2000
Inventor
Benito Munoz
San Diego
CA, US
Elisabeth Albrecht
San Diego
CA, US
Ian Alexander McDonald
San Diego
CA, US
Agent
Stephanie L Heller Ehrman White & McAuliffe Seidman
Assignee
SIBIA Neurosciences
CA, US
IPC
A61K 38/00
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