06051648 is referenced by 500 patents and cites 144 patents.

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH.sub.2) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

Title
Crosslinked polymer compositions and methods for their use
Application Number
573799
Publication Number
6051648
Application Date
January 13, 1999
Publication Date
April 18, 2000
Inventor
Richard A Berg
Los Altos
CA, US
Frank A DeLustro
Belmont
CA, US
Woonza M Rhee
Palo Alto
CA, US
Agent
Foley & Lardner
Agent
Laurie A Axford
Assignee
Cohesion Technologies
CA, US
IPC
C08G 69/48
C08G 63/91
C08F 283/00
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