06042822 is referenced by 55 patents and cites 39 patents.

Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate-activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.

Title
Interferon polymer conjugates
Application Number
150643
Publication Number
6042822
Application Date
April 6, 1999
Publication Date
March 28, 2000
Inventor
Myung ok Park Cho
Seoul
KR
Carl W Gilbert
Powder Springs
GA, US
Agent
Roberts & Mercanti
Assignee
Enzon
NJ, US
IPC
C07K 14/56
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