06039972 is referenced by 5 patents and cites 7 patents.

A conformable wound dressing is prepared by producing a sub-confluent layer of cultured mammalian cells such as epithelial cells anchored to a surface of a synthetic polymeric film which is hydrophobic, non-inhibitory to cell growth and non-cytotoxic. The polymer may be ethylene-vinyl acetate copolymer or a blend of ethylene-vinyl acetate copolymer and polystyrene, and is preferably subjected to corona discharge to improve cell attachment. The polymeric film may be sterilized with ethylene oxide or by gamma-irradiation. Preferably, the polymeric film is a continuous film containing apertures formed by perforation before or after cell culture to provide an apertured wound dressing. In a preferred embodiment, a laminate is formed containing a sub-confluent layer of mammalian cells anchored to a surface of a continuous film of synthetic polymer having a plurality of thin and thick portions cast on and supported by a carrier layer having a plurality of raised portions. When the carrier layer is separated from the polymer film, the thin portions rupture to form apertures in the film to result in an apertured wound dressing. The layer of mammalian cells is formed on the polymeric film by culturing the cells in contact with the film such as when the film forms one wall of a culture vessel. In a preferred embodiment, the cells are cultured in a vessel having the laminate as one wall.

Title
Wound dressing containing mammalian cells anchored on hydrophobic synthetic polymer film
Application Number
752659
Publication Number
6039972
Application Date
January 20, 1998
Publication Date
March 21, 2000
Inventor
Stephen Michael Lang
Saffron Walden
GB
Yvonne Margaret Barlow
Sawston
GB
Agent
Graham & James
Assignee
Smith & Nephew
GB
IPC
A61F 13/00
C12N 5/00
C12N 11/08
A61L 15/00
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