06033665 is referenced by 31 patents and cites 11 patents.

The invention is directed to compositions and methods for modulating the adhesion of leukocytes to brain endothelial cells. More specifically, the present invention relates to the use of reagents to inhibit the binding of VLA-4 leukocyte cell surface receptors to brain endothelial adhesion molecules. Also provided are compositions and methods for treating brain inflammation. A method of inducing brain inflammation as well as an assay for testing anti-inflammatory agents is also provided.

Title
Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
Application Number
413274
Publication Number
6033665
Application Date
June 1, 1995
Publication Date
March 7, 2000
Inventor
Theodore A Yednock
Fairfax
CA, US
Agent
Townsend & Townsend & Crew
Assignee
Elan Pharmaceuticals
CA, US
IPC
A61K 39/395
A61K 38/00
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