06026320 is referenced by 337 patents and cites 5 patents.

Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy.

Title
Heart rate variability as an indicator of exercise capacity
Application Number
9/93118
Publication Number
6026320
Application Date
June 8, 1998
Publication Date
February 15, 2000
Inventor
Julio C Spinelli
Shoreview
MN, US
Veerichetty A Kadhiresan
Lino Lakes
MN, US
Gerrard M Carlson
Champlin
MN, US
Agent
Nikolai Merserau & Dietz P A
Assignee
Cardiac Pacemakers
MN, US
IPC
A61N 1/365
A61B 5/0456
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