06018678 is referenced by 184 patents and cites 66 patents.

Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).

Title
Transdermal protein delivery or measurement using low-frequency sonophoresis
Application Number
152442
Publication Number
6018678
Application Date
October 19, 1995
Publication Date
January 25, 2000
Inventor
Robert S Langer
Newton
MA, US
Daniel Blankschtein
Brookline
MA, US
Samir S Mitragotri
Cambridge
MA, US
Agent
Arnall Golden & Gregory
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61B 6/00
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