06017496 is referenced by 152 patents and cites 471 patents.

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

Title
Matrices with memories and uses thereof
Application Number
428662
Publication Number
6017496
Application Date
September 6, 1996
Publication Date
January 25, 2000
Inventor
Hanan Potash
La Jolla
CA, US
Chanfeng Zhao
San Diego
CA, US
Yozo Satoda
San Diego
CA, US
Gary S David
La Jolla
CA, US
Xiao Yi Xiao
San Diego
CA, US
Andrew E Senyei
La Jolla
CA, US
Zahra Parandoosh
San Diego
CA, US
Michael P Nova
Santa Fe
CA, US
Agent
Brown Martin Haller & McClain
Assignee
Irori
CA, US
IPC
C12Q 1/68
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