06013853 is referenced by 189 patents and cites 69 patents.

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts of bioactive agent is released, thereby promoting differentiation of cells. Method of making material includes step of applying vacuum to form pores. Implant material may be adapted for one phase implant (e.g., for bone or cartilage) or for two phase layered implant (e.g., for cartilage layer on top of bone layer).

Title
Continuous release polymeric implant carrier
Application Number
837401
Publication Number
6013853
Application Date
February 15, 1994
Publication Date
January 11, 2000
Inventor
Barbara D Boyan
San Antonio
TX, US
Kyriacos A Athanasiou
San Antonio
TX, US
Agent
Greenlee Winner and Sullivan P C
Assignee
The University of Texas System
TX, US
IPC
A61F 2/28
A61F 2/02
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