06001881 is referenced by 2 patents and cites 10 patents.

Benzoylguanidines of the formula I ##STR1## in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmic pharmaceuticals, having a cardioprotective component, which are also valuable for the prevention of ischemically induced damage, in particular in association with the triggering of ischemically induced cardiac arrhythmias. As a consequence of inhibiting the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for treating acute or chronic damage triggered by ischemia. In addition to this, they are notable for their strong inhibitory effect on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.

Title
Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them
Application Number
8/868750
Publication Number
6001881
Application Date
June 4, 1997
Publication Date
December 14, 1999
Inventor
Wolfgang Scholz
Eschborn
DE
Udo Albus
Florstadt
DE
Jan Robert Schwark
Frankfurt
DE
Hans Jochen Lang
Hofheim
DE
Heinz Werner Kleemann
Bischofsheim
DE
Joachim Brendel
Bad Vilbel
DE
Andreas Weichert
Egelsbach
DE
Agent
Finnegan Henderson Farabow Garrett & Dunner L
Assignee
Hoechst Aktiengesellschaft
DE
IPC
A61K 31/18
A61K 31/165
C07C 277/08
C07C 279/22
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