05990102 is referenced by 16 patents and cites 3 patents.

Compounds of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R.sup.3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA.sub.2 and thereof of use in treating atherosclerosis.

Title
Substituted azetidin-2-ones for treatment of atherosclerosis
Application Number
8/860162
Publication Number
5990102
Application Date
November 21, 1997
Publication Date
November 23, 1999
Inventor
David Graham Tew
Audubon
PA, US
Robert John Ife
Hertfordshire
GB
Colin Andrew Leach
Hertfordshire
GB
Dashyant Dhanak
West Chester
PA, US
Deirdre Mary Bernadette Hickey
Saffron Walden
GB
Agent
Charles M Kinzig
William T King
Wayne J Dustman
Assignee
SmithKline Beecham
GB
IPC
C07D 205/09
A61K 31/395
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