05989835 is referenced by 222 patents and cites 11 patents.

The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

Title
System for cell-based screening
Application Number
8/810983
Publication Number
5989835
Application Date
February 27, 1997
Publication Date
November 23, 1999
Inventor
D Lansing Taylor
Pittsburgh
PA, US
R Terry Dunlay
Pittsburgh
PA, US
Agent
David S McDonnell Boehnen Hulbert & Berghoff Harper
Assignee
Cellomics
PA, US
IPC
G01N 33/533
View Original Source