05981719 is referenced by 145 patents and cites 549 patents.

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.

Title
Macromolecular microparticles and methods of production and use
Application Number
28237
Publication Number
5981719
Application Date
December 14, 1998
Publication Date
November 9, 1999
Inventor
Frank J Riske
Stoughton
MA, US
Charles D Blizzard
West Roxbury
MA, US
Judith Sudhalter
Newton
MA, US
Jie Di
Norwood
MA, US
Terrence L Scott
Winchester
MA, US
Larry R Brown
Newton
MA, US
James E Woiszwillo
Milford
MA, US
Agent
Jones & Askew
Assignee
Epic Therapeutics
MA, US
IPC
B01N 33/544
C08H 1/02
C07K 1/00
C07K 17/02
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