Water soluble paclitaxel prodrugs United States Patent 05977163

05977163 is referenced by 222 patents and cites 18 patents.

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.

Title
Water soluble paclitaxel prodrugs
Application Number
8/815104
Publication Number
5977163
Application Date
March 11, 1997
Publication Date
November 2, 1999
Inventor
David J Yang
Sugar Land
TX, US
Dong Fang Yu
Houston
TX, US
Sidney Wallace
Houston
TX, US
Chun Li
Missouri City
TX, US
Agent
Arnold White & Durkee
Assignee
PG TXL Company
TX, US
IPC
A61B 5/055
A61K 51/04
C07D 305/00
A01N 43/02
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Citations: 222 (view full list)

  1. Dachuan Yang, Joel L Stanslaski, Lixiao Wang, Scott R Smith: Stent coating. SciMed Life Systems, Crompton Seager & Tufte, July 10, 2001: US06258121 (455 worldwide citation)
  2. Carl J Evens, Kevin Weedock: Drug releasing anastomosis devices and methods for treating anastomotic sites. Ethicon, Carl J Evens, September 19, 2006: US07108701 (362 worldwide citation)
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  4. Bruce H KenKnight, Jay A Warren, Stephen John Hahn: Method for reducing restenosis in the presence of an intravascular stent. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, September 6, 2005: US06939345 (139 worldwide citation)
  5. Bruce H KenKnight, Jay A Warren, Stephen John Hahn: Method and system for reducing arterial restenosis in the presence of an intravascular stent. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, November 13, 2001: US06317615 (113 worldwide citation)
  6. Robert Falotico, John Spaltro: Coated medical devices for the treatment of vulnerable plaque. Cordis Corporation, March 27, 2007: US07195640 (80 worldwide citation)
  7. James J Barry, Kalpana R Kamath: Optimized dosing for drug coated stents. Boston Scientific SciMed, Kenyon & Kenyon, June 21, 2005: US06908622 (79 worldwide citation)
  8. Gerard H Llanos, David Christian Lentz: Local drug delivery devices and methods for maintaining the drug coatings thereon. Cordis Corporation, Carl J Evens, August 28, 2007: US07261735 (64 worldwide citation)
  9. Travis Mickle, Suma Krishnan, Barney Bishop, Christopher Lauderback, James Scott Moncrief, Rob Oberlender, Thomas Piccariello: Abuse-resistant amphetamine compounds. New River Pharmaceuticals, Hunton & Williams, September 12, 2006: US07105486 (52 worldwide citation)
  10. Luis A Davila, David Christian Lentz, Gerard H Llanos, Jorge Orlando Mendez, Pallassana V Narayanan, Alan Roy Pelton, Mark B Roller, Karl K Scheidt, Angelo George Scopelianos, William Douglas Shaw Jr, James H Silver, John Spaltro, Christine Trepanier, David J Wilson: Medical devices, drug coatings and methods for maintaining the drug coatings thereon. Ethicon USA, June 6, 2006: US07056550 (48 worldwide citation)

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