05977163 is referenced by 222 patents and cites 18 patents.

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.

Title
Water soluble paclitaxel prodrugs
Application Number
8/815104
Publication Number
5977163
Application Date
March 11, 1997
Publication Date
November 2, 1999
Inventor
David J Yang
Sugar Land
TX, US
Dong Fang Yu
Houston
TX, US
Sidney Wallace
Houston
TX, US
Chun Li
Missouri City
TX, US
Agent
Arnold White & Durkee
Assignee
PG TXL Company
TX, US
IPC
A61B 5/055
A61K 51/04
C07D 305/00
A01N 43/02
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