05972199 is referenced by 711 patents and cites 15 patents.

A sensor for the detection and measurement of an analyte in a biofluid. The sensor includes two enzymes. One type of sensor measures the concentration of hydrogen peroxide using a thermostable peroxidase enzyme that is immobilized in a redox hydrogel to form a sensing layer on a working electrode. This sensor also includes a hydrogen peroxide-generating second enzyme which is insulated from the redox hydrogel and electrode. This second enzyme generates hydrogen peroxide in response to the presence of an analyte or analyte-generated compound. The second enzyme may be insulated from the electrode by placement of an electrically insulating layer between the sensing layer and the second enzyme layer.

Title
Electrochemical analyte sensors using thermostable peroxidase
Application Number
540789
Publication Number
5972199
Application Date
February 11, 1997
Publication Date
October 26, 1999
Inventor
Mark S Vreeke
Alameda
CA, US
Adam Heller
Austin
TX, US
Agent
Merchant Gould Smith Edell Welter & Schmidt P A
Assignee
E Heller & Company
CA, US
IPC
G01N 27/26
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